Both coffee and opium come from plants. Why embrace one and not the other?

An internet huckster got rich selling a sex enhancement supplement named Stiff Nights. Then the FDA sampled his wares.

The line between legal pharmaceuticals and illegal drugs has less to do with science than with race, class, and gender.

They seeded medical breakthroughs and emerging markets. Now expunge their criminal records and let them go legit.

Traditional treatments often take place in expensive facilities, demand total abstinence, and rely on punitive methods of control. A harm reduction model turns all of that on its head.

How the seizure of Europe's largest heroin shipment created bloody fallout throughout the world—and sparked still-raging political corruption scandals in Turkey, Greece, and the Middle East

“Any gains we made in funding for health departments, syringe exchanges, naloxone distribution—it’s all at risk.”

Netflix’s documentary captures the newfound acceptability of mind-altering substances.

From alcohol to amphetamines, a new book shows intimate links between the policing of substances and the waging of war.

The progressive prosecutor wants to fight gun violence with a light touch. His critics say he’s crazy. His defenders say he’s onto something.

Or are they just looking to cut a deal for the sake of cutting a deal?

Stripped of the region’s coal and ravaged by drugs, the people of Appalachia are fighting to survive.

An elite police squad was supposed to clean up the streets of 1970s Detroit. Instead, it terrorized African Americans, and turned the city into a battleground.

Now that microdosing has brought back LSD, is it time for women to finally enjoy mind-altering drugs?

The ugly motive behind a beautiful diagram of old Chinatown

Against "rock bottom"